1789738-04-0
中文名稱
AMY-101 TFA
英文名稱
Cp40 TFA
CAS
1789738-04-0
分子式
C85H118F3N23O20S2
分子量
1903.14
MOL 文件
1789738-04-0.mol
1789738-04-0 結(jié)構(gòu)式
AMY-101 TFA價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | HY-P1717A | AMY-101 TFA | 1789738-04-0 | 1mg | 1200元 |
| 2024/11/08 | HY-P1717A | AMY-101 TFA | 1789738-04-0 | 5mg | 3200元 |
| 2024/11/08 | HY-P1717A | AMY-101 TFA | 1789738-04-0 | 10mg | 5000元 |
常見問題列表
生物活性
AMY-101 TFA (Cp40 TFA) 是補體 C3 的肽類抑制劑 (KD = 0.5 nM)，可抑制非人類靈長類動物自然發(fā)生的牙周炎。AMY-101 TFA (Cp40 TFA) 在 COVID-19 重癥肺炎合并全身超炎癥模型中具有良好的抗炎活性。靶點
KD: 0.5 nM (C3).
體內(nèi)研究
AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis.
AMY-101 can induce a long-lasting anti-inflammatory effect.
AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction.
| Animal Model: | Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old; 5.0-7.6 kg body weight). |
| Dosage: | 0.1 mg/site; 50 μL of 2 mg/mL solution. |
| Administration: | Injected locally. (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment.) |
| Result: | Does not cause irritation in healthy gingiva. |