178451-13-3
中文名稱(chēng)
RALOXIFENE6-MONOMETHYLETHER
CAS
178451-13-3
分子式
C29H29NO4S
分子量
487.61
MOL 文件
178451-13-3.mol
178451-13-3 結(jié)構(gòu)式
基本信息
英文別名
Raloxifene Impurity 22Raloxifene 6-Methoxy Analog
Raloxifene 6-MonoMethyl Ether
Methanone, [2-(4-hydroxyphenyl)-6-methoxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-
常見(jiàn)問(wèn)題列表
生物活性
Raloxifene 6-Monomethyl Ether 是一種 Raloxifene 衍生物，其抑制雌激素受體 α (estrogen receptor α)。Raloxifene 4-Monomethyl Ether 抑制 MCF-7 細(xì)胞，IC50 為 250 nM，pIC50 為 6.6。體外研究
Raloxifene 6-Monomethyl Ether (Compound 7) is a Raloxifene derivative with a methoxy group on C6. Raloxifene 6-Monomethyl Ether holds poor ICsub>50 value because of disruption to the hydrogen bond network and steric disfavor.