1781934-50-6
中文名稱
AR-C102222 HYDROCHLORIDE
英文名稱
AR-C102222 hydrochloride
CAS
1781934-50-6
分子式
C19H17ClF2N6O
分子量
418.83
MOL 文件
1781934-50-6.mol
1781934-50-6 結(jié)構(gòu)式
常見問題列表
生物活性
AR-C102222 hydrochloride 是一種有效的、競(jìng)爭(zhēng)性的、有口服活性的、高度選擇性的誘導(dǎo)型一氧化氮合酶 (iNOS) 抑制劑，IC50 值為 37 nM。AR-C102222 hydrochloride 具有鎮(zhèn)痛和抗炎活性。體內(nèi)研究
AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity.
AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model.
| Animal Model: | Male Balb/c mice (20-25 g). |
| Dosage: | 3, 10, 30, 100 mg/kg. |
| Administration: | P.O. 55 min before the administration of 0.6% acetic acid (i.p., 1 mL/100 g volume). |
| Result: | Significantly inhibited arachidonic acid-induced ear inflammation following a dose of 100 mg/kg of has a maximal inhibition of approximately 79%. |