175340-20-2
175340-20-2 結(jié)構(gòu)式
基本信息
中文別名
化合物S 18986化合物 T16816
英文別名
S 18986(3aS)-2,3,3a,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine 5,5-dioxide
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aS)-
所屬類別
生物化工：生化試劑物理化學(xué)性質(zhì)
沸點(diǎn)399.9±45.0 °C(Predicted)
密度1.46±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度在DMSO中溶解至50mM
酸度系數(shù)(pKa)9.88±0.20(Predicted)
形態(tài)粉末
顏色White to light yellow
S 18986價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-10936 | S 18986 | 175340-20-2 | 1 mg | 590元 |
| 2025/02/08 | HY-10936 | S 18986 S 18986 | 175340-20-2 | 5mg | 1300元 |
| 2025/02/08 | HY-10936 | S 18986 S 18986 | 175340-20-2 | 10 mM * 1 mLin DMSO | 1456元 |
常見問題列表
生物活性
S 18986 是一種選擇性的、口服活性的、腦滲透性的 AMPA-type 受體正向變構(gòu)調(diào)節(jié)劑。S 18986 顯示嚙齒動(dòng)物具有增強(qiáng)認(rèn)知能力的特性。S 18986 激活大鼠海馬去甲腎上腺素和乙酰膽堿的釋放，增強(qiáng)大鼠在物體識(shí)別實(shí)驗(yàn)中的記憶。體內(nèi)研究
S 18986 is robust memory-enhancing effects in middle-aged animals compared with aged ones. S 18986 shows antiamnesic properties in middle-aged rodents in spatial memory models .
S 18986 (5-50 mg/kg; i.p.) significantly increases both the induction and the maintenance of 4 and 20 bursts tetanus-evoked potentiation.
| Animal Model: | Middle-aged (14-15-months-old) mice |
| Dosage: | 0.3, 1, and 10 mg/kg |
| Administration: | p.o. |
| Result: | Showed antiamnesic properties in middle-aged rodents. |