1700637-55-3
中文名稱
CD38 inhibitor
英文名稱
CD38 inhibitor 78c
CAS
1700637-55-3
分子式
C22H27N3O3S
分子量
413.53
MOL 文件
1700637-55-3.mol
更新日期
2024/12/26 17:36:52
1700637-55-3 結(jié)構(gòu)式
基本信息
中文別名
化合物CD38 INHIBITOR 14-((反式-4-(2-甲氧基乙氧基)環(huán)己基)氨基)-1-甲基-6-(噻唑-5-基)喹啉-2(1H)-酮
英文別名
cd38-1CD38 inhibitor 1
CD38 inhibitor 78c
CD38 inhibitor 1 (compound 78c)
CD38 inhibitor 1,Inhibitor,inhibit,CD-38 inhibitor 1
4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-2(1H)-Quinolinone
4-((trans-4-(2-Methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one
2(1H)-Quinolinone, 4-[[trans-4-(2-methoxyethoxy)cyclohexyl]amino]-1-methyl-6-(5-thiazolyl)-
所屬類別
生物化工：抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)589.8±50.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO : 25 mg/mL (60.46 mM; ultrasonic and warming and heat to 60°C)
酸度系數(shù)(pKa)3.17±0.20(Predicted)
形態(tài)固體
顏色Light yellow to brown
InChIInChI=1S/C22H27N3O3S/c1-25-20-8-3-15(21-13-23-14-29-21)11-18(20)19(12-22(25)26)24-16-4-6-17(7-5-16)28-10-9-27-2/h3,8,11-14,16-17,24H,4-7,9-10H2,1-2H3/t16-,17-
InChIKeyVJQALSOBHVEJQM-QAQDUYKDSA-N
SMILESN1(C)C2=C(C=C(C3SC=NC=3)C=C2)C(N[C@@H]2CC[C@@H](OCCOC)CC2)=CC1=O
CD38 inhibitor 價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-123999 | CD38 inhibitor CD38 inhibitor 1 | 1700637-55-3 | 1mg | 600元 |
| 2024/11/08 | HY-123999 | CD38 inhibitor CD38 inhibitor 1 | 1700637-55-3 | 10mM * 1mLin DMSO | 1370元 |
| 2024/11/08 | S8960 | CD38 inhibitor CD38 inhibitor 1 (compound 78c) | 1700637-55-3 | 5mg | 1470元 |
常見問(wèn)題列表
生物活性
CD38 inhibitor 1 (compound 78c, CD38-IN-78c, MDK-7553)是一種有效的 CD38 抑制劑，對(duì)人CD38和小鼠CD38的IC50分別為7.3 nM和1.9 nM。靶點(diǎn)
| Target | Value |
|
mCD38
(Cell-free assay) | 1.9 nM |
|
hCD38
(Cell-free assay) | 7.3 nM |
體內(nèi)研究
CD38 inhibitor (30 mg/kg; oral administration; 2 and 6 hours) significantly elevates NAD levels in liver and muscle.
| Animal Model: | Diet induced obese (DIO) C57Bl6 mice |
| Dosage: | 30 mg/kg |
| Administration: | Orally once |
| Result: | NAD levels were significantly increased at both the 2 and 6 h time points in liver and muscle. |