1644443-92-4
中文名稱(chēng)
化合物GW406108X
英文名稱(chēng)
GW406108X
CAS
1644443-92-4
分子式
C20H11Cl2NO4
分子量
400.21
MOL 文件
1644443-92-4.mol
1644443-92-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)639.3±55.0 °C(Predicted)
密度1.527±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 62.5 mg/mL (156.17 mM)
酸度系數(shù)(pKa)6.35±0.40(Predicted)
形態(tài)Solid
顏色Light yellow to yellow
常見(jiàn)問(wèn)題列表
生物活性
GW406108X 是特異性的 Kif15 (Kinesin-12) 抑制劑，IC50 為 0.82 uM。GW406108X 是一種有效的自噬 (autophagy) 抑制劑, ATP 競(jìng)爭(zhēng)性抑制 ULK1，pIC50 為 6.37 (427 nM)。GW406108X 抑制 ULK1 和自噬，而不影響 mTOR 或 AMPK 活性。體外研究
GW406108X acts upon ULK1 and autophagy without affecting mTOR or AMPK activity as shown by monitoring ULK1 pS758 (mTOR site) or pS556 (AMPK site) levels. GW406108X inhibits VPS34 and AMPK with pIC
50
of 6.34 (457 nM) and 6.38 (417 nM), respectively. In the presence of 5 μΜ GW406108X, the starvation-induced increase in ATG13 phosphorylation is significantly reduced.
GW406108X inhibits Kif15-N420 ATPase activity by 76%.