1621884-22-7
基本信息
AODDRWVLAXJCBA-UHFFFAOYSA-N
2'-Deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate sodium salt
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-15745A | 1621884-22-7 PSI-7409 tetrasodium | 1621884-22-7 | 1mg | 2600元 |
2024/08/19 | HY-15745A | 1621884-22-7 PSI-7409 tetrasodium | 1621884-22-7 | 5mg | 7800元 |
2023/03/20 | HY-15745A | 1621884-22-7 PSI-7409 tetrasodium | 1621884-22-7 | 10mg | 12000元 |
常見問題列表
IC50: 1.6 μM (GT 1b_Con1), 2.8 μM (GT 2a_JFH1), 0.7 μM (GT 3a), 2.6 μM (GT 4a)
PSI-7409 tetrasodium is an active 5'-triphosphate metabolite, inhibiting HCV NS5B polymerases, with IC 50 s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively. PSI-7409 also weakly inhibits human DNA polymerase α, with an IC 50 of 550 μM, but shows no inhibition on DNA Pol β and γ. In clone A cells, the levels of PSI-7409 gradually increases to a maximum concentration of about 25 μM over a period of 48 h. PSI-7409 forms at a much faster rate in primary human hepatocytes, achieving a maximum intracellular concentration of ~100 μM at 4 h and remains at that concentration for 48 h.