1621717-95-0
中文名稱
SPACE peptide
英文名稱
SPACE peptide
CAS
1621717-95-0
分子式
C??H??N??O??S?
分子量
1090.15
1621717-95-0 結(jié)構(gòu)式
基本信息
中文別名
SPACE肽H-ALA-CYS-THR-GLY-SER-THR-GLN-HIS-GLN-CYS-GLY-OH(DISULFIDE BRIDGE:CYS2-CYS10)
英文別名
SPACE peptideSPACE peptide,AC-TGSTQHQ-CG,Disulfide Bridge 2–10
所屬類別
生物化工:多肽物理化學(xué)性質(zhì)
沸點1870.9±65.0 °C(Predicted)
密度1.54±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
酸度系數(shù)(pKa)3.57±0.10(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
SPACE peptide 是一種皮膚穿透肽 (SPPs)。SPACE peptide 能增強(qiáng)大分子透明質(zhì)酸的局部傳遞。體外研究
SPACE peptide, when conjugates to cargoes such as small molecules and proteins, is able to facilitate their penetration across the stratum corneum into epidermis and dermis.
SPACE peptide also exhibits increased penetration into various cells including keratinocytes, fibroblasts, and endothelial cells, likely through a macropinocytosis pathway.
SPACE peptide enhances Cyclosporine A skin penetration, via a transcellular pathway, enhancing its partitioning into keratin-rich corneocytes through concurrent binding of SPACE with keratin and Cyclosporine A.