161922-40-3
中文名稱
鹽酸阿西維辛
英文名稱
Acivicin hydrochloride
CAS
161922-40-3
分子式
C5H8Cl2N2O3
分子量
215.03
MOL 文件
161922-40-3.mol
161922-40-3 結(jié)構(gòu)式
常見問題列表
生物活性
Acivicin hydrochloride (AT-125 hydrochloride) 是一種由豬鏈霉菌產(chǎn)生的天然產(chǎn)物，是 γ-谷氨酰轉(zhuǎn)肽酶 (GGT) 抑制劑。Acivicin hydrochloride 可以透過血腦屏障，并具有抗癌，抗寄生蟲的特性。靶點(diǎn)
γ-glutamyl transpeptidase
體外研究
Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC 50 of 0.7 μM in human HepG2 cells.
體內(nèi)研究
Acivicin hydrochloride (AT-125 hydrochloride; 5 mg/kg; IP; twice weekly) reduces urinary γ-GT by 70-78%.
| Animal Model: | Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene |
| Dosage: | 5 mg/kg |
| Administration: | IP; twice weekly (monday and wednesday) |
| Result: | Reduced urinary γ-GT by 70-78%. |