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159237-99-7

中文名稱 159237-99-7
英文名稱 Phe-Met-Arg-Phe amide trifluoroacetate
CAS 159237-99-7
分子式 C33H44F6N8O8S
分子量 826.807
MOL 文件 159237-99-7.mol
更新日期 2024/10/24 11:51:23
159237-99-7 結(jié)構(gòu)式 159237-99-7 結(jié)構(gòu)式

基本信息

中文別名
心興奮肽H-PHE-MET-ARG-PHE-NH2
英文別名
Phe-Met-Arg-Phe amide trifluoroacetate
PHE-MET-ARG-PHE AMIDE TRIFLUOROACETATE?, >98%
Phe-Met-Arg-Phe amide trifluoroacetate,Phe-Met-Arg-Phe-NH2 trifluoroacetate,FMRF-NH2 trifluoroacetate?, >98%
所屬類別
生物化工:氨基酸及其衍生物

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
形態(tài)Solid
顏色White to off-white
水溶解性Water : ≥ 50 mg/mL (60.47 mM)
序列H-Phe-Met-Arg-Phe-NH2
Phe-Met-Arg-Phe amide價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19HY-P0249A159237-99-7
Phe-Met-Arg-Phe amide trifluoroacetate
159237-99-75mg950元
2024/08/19HY-P0249A159237-99-7
Phe-Met-Arg-Phe amide trifluoroacetate
159237-99-710mg1550元
2024/08/19HY-P0249A159237-99-7
Phe-Met-Arg-Phe amide trifluoroacetate
159237-99-725mg2280元

常見問題列表

生物活性
Phe-Met-Arg-Phe amide trifluoroacetate 是一種神經(jīng)肽,在肽能神經(jīng)元中激活 K+ 電流,ED50 為 23 nM,這種作用具有劑量依賴性。
靶點(diǎn)

ED50: 23 nM (K + current)

體外研究

In the molluscan central nervous system, Phe-Met-Arg-Phe amide (FMRFa) acts on K + channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe amide activates a novel K + current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe amide (FMRF-NH2) (1 and 10 μM) is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM).

體內(nèi)研究

Phe-Met-Arg-Phe amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min.

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