159237-99-7
基本信息
PHE-MET-ARG-PHE AMIDE TRIFLUOROACETATE?, >98%
Phe-Met-Arg-Phe amide trifluoroacetate,Phe-Met-Arg-Phe-NH2 trifluoroacetate,FMRF-NH2 trifluoroacetate?, >98%
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/08/19 | HY-P0249A | 159237-99-7 Phe-Met-Arg-Phe amide trifluoroacetate | 159237-99-7 | 5mg | 950元 |
2024/08/19 | HY-P0249A | 159237-99-7 Phe-Met-Arg-Phe amide trifluoroacetate | 159237-99-7 | 10mg | 1550元 |
2024/08/19 | HY-P0249A | 159237-99-7 Phe-Met-Arg-Phe amide trifluoroacetate | 159237-99-7 | 25mg | 2280元 |
常見問題列表
ED50: 23 nM (K + current)
In the molluscan central nervous system, Phe-Met-Arg-Phe amide (FMRFa) acts on K + channels in sensory, motor-, and neuroendocrine neurones. Phe-Met-Arg-Phe amide activates a novel K + current that is characterized by a combined voltage- and receptor-dependent gating mechanism, with both factors being necessary for opening of the channels. Phe-Met-Arg-Phe amide (1 μM) significantly inhibits glucose stimulated (300 mg/dL) insulin release (p<0.005) and somatostatin release (p<0.01) from the isolated perfused pancreas. Phe-Met-Arg-Phe amide (FMRF-NH2) (1 and 10 μM) is without effect on glucagon secretion, either in low glucose (50 mg/dL), high glucose (300 mg/dL), or during arginine stimulation (5 mM).
Phe-Met-Arg-Phe amide (FMRFamide) stimulates growth hormone secretion in conscious OVX rats. The presence of Phe-Met-Arg-Phe amide-like immunoreactivity in neuronal elements in the hypothalamus suggested a role for this in the hypothalamic control of the anterior pituitary function. The injection of 200 ng (313.8 picomoles) of FMRFamide (in 2 uL) produces a significantly increased plasma GH 15 min after injection. The GH-increasing effect of 400-800 ng (627-1255 picomoles) of FMRFamide is already developed after 5 min and lasted up to 30 min.