159190-45-1
中文名稱
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
英文名稱
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
CAS
159190-45-1
分子式
C8H19Cl2N3O2
分子量
260.16
MOL 文件
159190-45-1.mol
159190-45-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T25749 英文別名
L-NIL HCLL-NIL DIHYDROCHLORIDE
L-N6-(1-Iminoethyl)lysine
OQIBCXRAFAHXMM-KLXURFKVSA-N
L-N6-(1-IMINOETHYL)-LYSINE 2HCL
L-N6-(1-IMINOETHYL)LYSINE, DIHCL
L-Lysine ω-acetamidine dihydrochloride
L-N6-(1-IMINOETHYL)LYSINE DIHYDROCHLORIDE
N6-(1-IMINOETHYL)-L-LYSINE DIHYDROCHLORIDE
L-Lysine, N6-(1-iMinoethyl)-, (Hydrochloride) (1:2)
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C
溶解度DMF: 15 mg/mL; DMSO: 15 mg/mL; Ethanol: 1 mg/mL; PBS: 30 mg/mL; Water: 50 mg/ml
形態(tài)白色至類白色固體
安全數(shù)據(jù)
常見問題列表
生物活性
L-NIL dihydrochloride 是誘導(dǎo)型一氧化氮合成酶 (iNOS) 的抑制劑，其對(duì) miNOS 的 IC50 值為3.3 μM。靶點(diǎn)
IC50: 3.3 μM (mouse inducible NO synthase), 92 μM (rat brain constitutive NO synthase).
體外研究
L-NIL produces a concentration-dependent inhibition of both the mouse inducible NOS (miNOS) and the rat brain constitutive NOS (rcNOS) and is considerably more potent for miNOS. The IC 50 values for L-NIL with miNOS and rcNOS are 3.3 and 92 pM, respectively, indicating that L-NIL is 28-fold more selective for miNOS. In addition, L-NIL has approximately 6-fold greater potency for miNOS than either L-NMA or L-NNA.
體內(nèi)研究
L-NIL (10 and 30?mg/kg, IP) prevents the inflammation, oxidative stress and autophagy induced by renal IR in mice.
| Animal Model: | Adult male Balb/c (20-25 g). |
| Dosage: | 10 and 30?mg/kg. |
| Administration: | Intraperitoneally at the end of CLP and at 6?h after sepsis induction. |
| Result: |
Led to a negligible increase in plasma NGAL compared to sham mice.
Led to a significant decrease in both TLR4 and IL1β?protein contents and clusterin transcript. Showed an increase in NFAT5 mRNA levels, as compared with mice treated with vehicle. Promoted a decrease in AR protein expression, as compared with animals treated with vehicle. |