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15866-90-7

中文名稱 INCYCLINIDE (CMT-3, COL-3)
英文名稱 Incyclinide
CAS 15866-90-7
分子式 C19H17NO7
分子量 371.34
MOL 文件 15866-90-7.mol
15866-90-7 結(jié)構(gòu)式 15866-90-7 結(jié)構(gòu)式

基本信息

中文別名
MMP抑制劑(INCYCLINIDE)
英文別名
COL 3
CMT 3
Metastat
NSC 683551
Incyclinide
INCYCLINIDE (CMT-3, COL-3)
2-NaphthacenecarboxaMide,1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4aS,5aR,12aS)-

物理化學性質(zhì)

熔點228-231 °C
沸點752.8±60.0 °C(Predicted)
密度1.70±0.1 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度DMSO:100.0(Max Conc. mg/mL);269.29(Max Conc. mM)
酸度系數(shù)(pKa)4.50±1.00(Predicted)
形態(tài)固體
顏色Light yellow to yellow
INCYCLINIDE (CMT-3, COL-3)價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/08/19HY-13648INCYCLINIDE (CMT-3, COL-3)
Incyclinide
15866-90-71mg780元
2024/08/19HY-13648INCYCLINIDE (CMT-3, COL-3)
Incyclinide
15866-90-75mg1200元
2024/08/19HY-13648INCYCLINIDE (CMT-3, COL-3)
Incyclinide
15866-90-710mM * 1mLin DMSO1320元

常見問題列表

生物活性
Incyclinide (CMT-3, COL-3) 是一種基質(zhì)金屬蛋白酶 (MMP) 抑制劑,誘導細胞外基質(zhì)降解,抑制血管生成,腫瘤生長和侵襲以及轉(zhuǎn)移。
體外研究

Incyclinide has been shown to experimentally suppress prostate cancer, colon adenocarcinoma and melanoma invasiveness in cell culture. Adding incyclinide at final concentrations of 5 to 20 μM inhibits MT1-MMP gelatinolytic and caseinolytic activity, blocks MT1-MMPactivation of pro-MMP-2, and decreases invasiveness of HT-1080 fibrosarcoma cells. Incyclinide is an especially effective inhibitor of the growth and viability of filamentous fungi. Most of the MICs of CMT-3 against filamentous fungi are found to be between 0.25 and 8 μg/mL, and the inhibition of viability of these fungi by incyclinide is routinely higher than 90%.

體內(nèi)研究

Incyclinide inhibits tooth movement in the rat, probably by reducing the number of osteoclasts at the compression side. This might be due to induction of apoptosis in activated osteoclasts or reduced osteoclast migration. Reduced MMP activity by incyclinide might also directly inhibit degradation of the organic bone matrix.

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