157124-84-0
中文名稱
1-phosphono-4-(3-phenoxyphenyl) butylsulfonic acid tripotassiuM salt
英文名稱
1-phosphono-4-(3-phenoxyphenyl) butylsulfonic acid tripotassiuM salt
CAS
157124-84-0
分子式
C16H16K3O7PS
分子量
500.628
MOL 文件
157124-84-0.mol
157124-84-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10587 英文別名
BPH-652BPH 652,BPH652
FIOQVVKPUBNHEM-UHFFFAOYSA-N
1-phosphono-4-(3-phenoxyphenyl) butylsulfonic acid tripotassiuM salt
物理化學(xué)性質(zhì)
儲存條件4°C, away from moisture
形態(tài)Solid
顏色White to off-white
水溶解性Water : 25 mg/mL (49.94 mM; Need ultrasonic)
常見問題列表
生物活性
BPH-652 是 CrtM 的抑制劑，Ki 值為 1.5 nM，IC50 值為100-300 nM (S. aureus 色素形成)。靶點(diǎn)
Ki: 1.5 nM (CrtM).
IC50: 100-300 nM (
S. aureus
pigment formation).
體內(nèi)研究
BPH-652 treatment (0.5 mg twice per day (days ?1, 0, 1, and 2), Intraperitoneal injection) significantly lowers S. aureus bacterial counts in the kidneys of the mice than those of the control group (P < 0.001), with 8 of 13 below the detection threshold, versus only 2 of 14 in the control group; on average, this result corresponds to a 98% decrease in surviving bacteria in the treatment group.
| Animal Model: | A systemic S. aureus infection model in mice. |
| Dosage: | 0.5 mg twice per day (days ?1, 0, 1, and 2). |
| Administration: | Intraperitoneal injection. |
| Result: | S. aureus bacterial counts in the kidneys of the mice treated with BPH-652 were significantly lower than those of the control group. |