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15442-64-5

中文名稱 鋅原卟啉
英文名稱 PROTOPORPHYRINATO ZINC
CAS 15442-64-5
分子式 C34H32N4O4Zn
分子量 626.03
MOL 文件 15442-64-5.mol
更新日期 2024/10/29 10:09:23
15442-64-5 結(jié)構(gòu)式 15442-64-5 結(jié)構(gòu)式

基本信息

中文別名
鋅原卟啉
原卟啉鋅
三水合原卟啉鋅
原卟啉鋅(II)
三水合原卟啉鋅,96%
鋅原卟啉(ZNPPIX)
原卟啉 IX 鋅(II) 絡(luò)合物
3,3'-(3,8,13,17-四甲基-7,12-二乙烯基卟啉-2,18-二基)二丙酸鋅
英文別名
ZnPP
PROTOPORPHYRINATO ZINC
Zinc protoporphyrin trihydrate
Zinc protoporphyrin trihydrate, 95+%
PROTOPORPHYRINATO ZINC ISO 9001:2015 REACH
Zinc Protoporphyrin IX DISCONTINUED, offer Z439970
Zinc (II) Protoporphyrin IX - CAS 15442-64-5 - Calbiochem
Zinc(II) 3,3'-(3,8,13,17-tetramethyl-7,12-divinylporphyrin-2,18-diyl)dipropionate
dihydrogen [3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-N21,N22,N23,N24]zincate(4-)
所屬類別
有機(jī)原料:磺酸類氨基化合物

物理化學(xué)性質(zhì)

RTECS號(hào)ZG9210300
儲(chǔ)存條件Store at RT
溶解度DMSO : 50 mg/mL (79.87 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
形態(tài)Crystalline
顏色暗紅色至紫色
水溶解性Insoluble in water. Soluble in ethanol, and DMSO, pyridine, or dimethyl formamide.

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
WGK Germany3
TSCAYes
鋅原卟啉價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19032068三水合原卟啉鋅, 96%
Zinc protoporphyrin, 96%
15442-64-510mg724元
2024/08/19032068三水合原卟啉鋅, 96%
Zinc protoporphyrin, 96%
15442-64-550mg2048元
2024/08/19032068原卟啉鋅
Zinc protoporphyrin
15442-64-50.25g8005元

常見問題列表

生物活性
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一種具有口服活性的,競(jìng)爭(zhēng)性的血紅素加氧酶-1 (HO-1) 抑制劑,顯著減弱間苯三酚 (PG) 對(duì) H2O2 的保護(hù)作用。Zinc Protoporphyrin 可用作個(gè)體孕婦和兒童缺鐵的篩查標(biāo)志物,也用于評(píng)估人群鐵狀態(tài)與血紅蛋白濃度的組合。Zinc Protoporphyrin 具有抗癌活性。
靶點(diǎn)

Human Endogenous Metabolite

體外研究

Zinc Protoporphyrin (Zn(II)-protoporphyrin IX; 5 μM; 72 hours) causes the fraction of late apoptotic and necrotic cells increasing from 10.9% in controls to 30.4% after 72 h.
Zinc Protoporphyrin (1.25-40 μM; 48 or 72 hours) exerts cystostatic/cytotoxic effects against tumor cells.
Zinc Protoporphyrin (2.5, 5 μM; 48 or 72 hours) results in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.
Zinc Protoporphyrin (1.25-40 μM; 48 hours) leads to accumulation of cleaved (active) caspase-3.

Apoptosis Analysis

Cell Line: C-26 cells
Concentration: 5 μM
Incubation Time: 72 hours
Result: The fraction of late apoptotic and necrotic cells increased from 10.9% in controls to 30.4% after 72 h.

Cell Cytotoxicity Assay

Cell Line: C-26 and MDA-MB231 cells
Concentration: 1.25, 2.5, 5, 10, 20, 40 μM
Incubation Time: 48 or 72 hours
Result: Exerted cystostatic/cytotoxic effects against tumor cells.

Cell Cycle Analysis

Cell Line: C-26 cells
Concentration: 2.5, 5 μM
Incubation Time: 48 or 72 hours
Result: Resulted in dose- and time-dependent reduction of cells in G1 phase of the cell cycle.

Western Blot Analysis

Cell Line: C-26 cells
Concentration: 1.25, 2.5, 5, 10, 20, 40 μM
Incubation Time: 48 hours
Result: Leaded to accumulation of cleaved (active) caspase-3.
體內(nèi)研究

Zinc Protoporphyrin (12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.; from day 7 to 19) exerts dose-dependent antitumor effects manifested by the retardation of tumor growth.

Animal Model: BALB/c mice inoculated with C-26 cells
Dosage: 12.5, 25, 50 mg/kg for i.p.; 12.5, 50 mg/kg for p.o.
Administration: IP or PO; from day 7 to 19
Result: Exerted dose-dependent antitumor effects manifested by the retardation of tumor growth.
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