152633-54-0
152633-54-0 結構式
基本信息
中文別名
化合物 T13340 英文別名
WIN 620052H-Imidazo[4,5-b]pyridin-2-one, 1,3-dihydro-5-methyl-6-(4-pyridinyl)-
常見問題列表
生物活性
Win-62005是一種環(huán)狀AMP磷酸二酯酶III (PDE III) 抑制劑，對于大鼠心臟和犬主動脈的 Ki 值分別為25和26 nM。靶點
Ki: 25 nM (PDE III), 25 nM (PDE III)
體外研究
Win-62005 competitively inhibits cyclic GMP-inhibitable low Km cyclic AMP phosphodiesterase (PDE III) from rat heart and canine aorta with K i values of 25±3 and 26±5 nM, respectively and is selective (at least 160-fold) for PDE III inhibition relative to other PDE isozymes.
體內研究
After p.o. administration of 1 mg/kg Win-62005, LVdP/dtmax is significantly increased in 30 min and remains increased for at least 6 h.