151227-08-6
151227-08-6 結(jié)構(gòu)式
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-100166 | 151227-08-6 AP521 | 151227-08-6 | 5 mg | 1700元 |
| 2025/02/08 | HY-100166 | 化合物 AP521 AP521 | 151227-08-6 | 10 mM * 1 mLin DMSO | 1870元 |
| 2025/02/08 | HY-100166 | 化合物 AP521 AP521 | 151227-08-6 | 10 mg | 3000元 |
常見(jiàn)問(wèn)題列表
|
5-HT 1A Receptor 94 nM (IC 50 , in human) |
5-HT 1A Receptor 135 nM (IC 50 , in rat) |
5-HT 1B Receptor 254 nM (IC 50 , in rat) |
5-HT 1B Receptor 5530 nM (IC 50 , in human) |
5-HT 1D Receptor 418 nM (IC 50 , in human) |
5-HT 5A Receptor 422 nM (IC 50 , in human) |
5-HT 7 Receptor 198 nM (IC 50 , in rat) |
AP521 is an agonist of human 5-HT 1A receptor with IC 50 s of 135, 94, 254, 5530, 418, 422 and 198 nM for 5-HT 1A (rat), 5-HT 1A (human), 5-HT 1B (rat), 5-HT 1B (human), 5-HT 1D (human), 5-HT 5a (human) and 5-HT 7 (rat), respectively. AP521 also decreases the forskolin-induced cAMP accumulation from 10 nM to 10 μM.
AP521 significantly increases the number of shock acceptances [F(5,105)=4.46, P<0.01] at doses between 0.5 to 10 mg/kg. Oral administration of AP521 at 3 and 10 mg/kg significantly decreases freezing time [F(3,60)=2.89, P<0.05]. AP521 significantly increases the time spent on the open arms by approximately 2-fold as compare to the vehicle treated group [F(3, 36)=4.21, P<0.05 for AP521]. The anxiolytic-like effect of AP521 appears to be dose-related. AP521 significantly increases the extracellular 5-HT level of the medial prefrontal cortex (mPFC) at 10 mg/kg from 0.5 to 1 h after administration. AP521 at 3 mg/kg tends to increase the extracellular 5-HT level, however, this increase is not significant.