1507930-57-5
中文名稱
Gap19
英文名稱
Gap19
CAS
1507930-57-5
分子式
C55H96N14O13
分子量
1161.44
MOL 文件
1507930-57-5.mol
更新日期
2024/10/20 11:27:43
1507930-57-5 結(jié)構(gòu)式
基本信息
中文別名
化合物GAP19 ACETATECX43 細胞質(zhì)環(huán) (CL) 九肽
英文別名
Gap19L-Lysine, L-lysyl-L-glutaminyl-L-isoleucyl-L-α-glutamyl-L-isoleucyl-L-lysyl-L-lysyl-L-phenylalanyl-
物理化學(xué)性質(zhì)
沸點1511.4±65.0 °C(Predicted)
密度1.212±0.06 g/cm3(Predicted)
儲存條件-20°C
溶解度≥58.07 mg/mL in H2O; insoluble in EtOH; ≥26.55 mg/mL in DMSO
酸度系數(shù)(pKa)3.30±0.10(Predicted)
形態(tài)粉末
顏色白色至灰白色
水溶解性Soluble to 2 mg/ml in water
常見問題列表
生物活性
Gap19 是一種衍生自 Cx43 細胞質(zhì)環(huán) (CL) 九個氨基酸的肽，一種有效的，選擇性連接蛋白 43 (Cx43) 半通道阻滯劑。Gap19 可以防止 C 末端 (CT) 與 CL 的分子內(nèi)相互作用。Gap19 不阻斷 GJ 通道或 Cx40/pannexin-1 半通道。Gap19 對心肌具有保護作用。靶點
Cx43 Hemichannel
體外研究
Gap19 (250 μM; for 30 min ) decreases mitochondrial potassium uptake.
Gap19 (400 μM) inhibits unitary hemichannel currents in HeLa-Cx43 cells.
Gap19 (100 μM) inhibits hemichannel unitary currents in ventricular cardiomyocytes.
Gap19 (250 μM, 30 min) protects against myocardial ischemia/reperfusion injury in vitro and in vivo.
體內(nèi)研究
Gap19 (iv; 25 mg/kg; 10 min before ligation) significantly reduces the infarct size by approximately one-fifth.
| Animal Model: | C57/BL6 mice |
| Dosage: | 25 mg/kg |
| Administration: | IV; 10 min before ligation |
| Result: | Significantly reduced the infarct size by approximately one-fifth. |