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150417-90-6

中文名稱 DHPS抑制劑
英文名稱 GC7 Sulfate
CAS 150417-90-6
更新日期 2024/06/03 14:41:41
分子式 C8H22N4O4S
分子量 270.35
MOL 文件 150417-90-6.mol
150417-90-6 結構式 150417-90-6 結構式

基本信息

中文別名
DHPS抑制劑(GC7 SULFATE)
英文別名
GC7 Sulfate
所屬類別
生物化工:抑制劑

物理化學性質

儲存條件-20°C儲存
溶解度10 mM AcOH: soluble
形態(tài)固體
顏色White to off-white
DHPS抑制劑價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2024/08/19HY-108314ADHPS抑制劑
GC7 Sulfate
150417-90-61mg550元
2024/08/19HY-108314ADHPS抑制劑
GC7 Sulfate
150417-90-65mg1200元
2024/08/19HY-108314ADHPS抑制劑
GC7 Sulfate
150417-90-610mM * 1mLin Water1640元

常見問題列表

生物活性
GC7 Sulfate 是一種脫氧嘌呤合成酶 (DHPS) 抑制劑。
靶點

DHPS

體外研究

The treatment of MYCN2 (±Dox) and BE(2)-C cells with GC7 Sulfate for 72 h at various concentrations (0.1 to 100 μM) significantly reduces the number of viable cells in a dose-dependent manner. In MYCN2 cells, 5 μM of GC7 Sulfate inhibits cell viability by ~40 and ~60 %, respectively, compare to untreated control cells. BE(2)-C cells require 25 μM of GC7 Sulfate to reduce cell viability by ~50 %. Exposure to 10 and 100 μM GC7 for 72 h clearly decreases the levels of total retinoblastoma (Rb) and phosphorylated Rb as well as of Cdk4 protein, and increases the levels of p21 protein. Between 0 and 20 μM, GC7 Sulfate induces little cytotoxicity in HCC cells, while higher concentrations of GC7 Sulfate (50 to 100 μM) significantly inhibit the viability of all five HCC cell lines tested. Newly synthesized 3 H-labeled hypusine of eIF5A1/eIF5A2 is rarely detected after 20 μM GC7 Sulfate treatment, compare to untreated control. The activity of [ 3 H]-spermidine incorporated into HCC cells is significantly decreased by 20 μM GC7 Sulfate or higher concentration.

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