成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

返回ChemicalBook首頁>CAS數(shù)據(jù)庫列表>14907-98-3

14907-98-3

中文名稱 鴉膽子苦醇
英文名稱 brusatol
CAS 14907-98-3
分子式 C26H32O11
分子量 520.53
MOL 文件 14907-98-3.mol
更新日期 2024/12/20 18:42:51
14907-98-3 結(jié)構(gòu)式 14907-98-3 結(jié)構(gòu)式

基本信息

中文別名
鴉膽苦醇
鴉膽子苦醇對照品
BRUSATOL 鴉膽子苦醇
英文別名
100935
Brusato1
Brustaol
Yatansin
NSC 172924
(+)-Brusatol
Brusatol >=95% (HPLC)
Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-
13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicras-3-en-21-oic acid methyl ester
13,20-Epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-butenyl)oxy]-2,16-dioxopicrasa-3-ene-21-oic acid methyl ester
所屬類別
生物化工:提取物

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶性粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來源于鴉膽子Brucea javanica。
沸點(diǎn)724.3±60.0 °C(Predicted)
密度1.46±0.1 g/cm3 (20 ºC 760 Torr)
儲存條件-20°C
溶解度DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
酸度系數(shù)(pKa)8.81±0.70(Predicted)
形態(tài)粉末
顏色白色至米色
旋光性 (optical activity)[α]/D +35 to +44°, c = 0.5 in acetone
LogP0.393 (est)

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335

應(yīng)用領(lǐng)域

用途1
一種來源于植物的天然類西林類藥物,通過抑制細(xì)胞蛋白的從頭合成,在腫瘤培養(yǎng)中表現(xiàn)出廣泛的細(xì)胞毒性。
鴉膽子苦醇價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08S7956鴉膽子苦醇
Brusatol
14907-98-32mg949.85元
2024/11/08S7956鴉膽子苦醇
Brusatol
14907-98-35mg1663.54元
2024/11/08S7956Brusatol14907-98-310mM (1mL in DMSO)1970元

常見問題列表

生物活性
Brusatol (NSC 172924),可分離自B. javanica果實(shí),是一種NRF2抑制劑。
靶點(diǎn)
TargetValue
Nrf2
()
體外研究

A potential therapeutic application of an Nrf2 inhibitor such as Brusatol (NSC 172924) is the downregulation of Nrf2 pathway components in cells harboring constitutively high levels of the transcription factor. Brusatol (NSC 172924) provokes the depletion of Nrf2 via a mechanism that is not dependent on Keap1 and the proteasomal and autophagic protein degradation systems. Brusatol (NSC 172924) provokes a rapid and transient depletion of Nrf2 protein, through a posttranscriptional mechanism, in mouse Hepa-1c1c7 hepatoma cells. Brusatol (NSC 172924) also inhibits Nrf2 in freshly isolated primary human hepatocytes. To explore the possible synergistic cytotoxicity of Brusatol (NSC 172924) in combination with CDDP, the study investigates the effects of Brusatol and CDDP cotreatment on CT-26 cell viability using an MTT assay. CT-26 cells are treated with various concentrations of Brusatol (0.05, 0.15, 0.45, 1.35, 4.05 and 12.15 μg/mL) and CDDP (0.05, 0.15, 0.45, 1.35, 4.05 and 12.15 μg/mL) for 48 h, either alone or in combination. Following treatment with Brusatol (NSC 172924) and CDDP for 48 h, the viability of CT-26 cells is reduced in a dose-dependent manner, with IC 50 values of 0.27±0.01 and 1.44±0.22 μg/mL, respectively. When Brusatol (NSC 172924) is combined with CDDP at a constant concentration ratio of 1:1, cell growth inhibition is markedly enhanced compared with single-agent treatment; the IC 50 value of Brusatol (NSC 172924) and CDDP cotreatment is 0.19±0.02 μg/mL.

體內(nèi)研究

To explore the anticancer effect of Brusatol in vivo, A549 xenografts grown in nude mice are used as a model. Nude mice are injected with A549 cells to induce tumor growth, followed by a single i.p. injection of 2 mg/kg Brusatol. Tumors are isolated 24 h or 48 h postinjection. Nrf2 protein levels are significantly decreased at 24 h or 48 h postinjection, indicating that Brusatol (NSC 172924) is able to reach the tumor tissue and inhibit the Nrf2 pathway. To measure tumor growth, two different experiments are performed. In the first experiment, once the tumor size reaches an average of 230 mm 3 , DMSO, Brusatol (NSC 172924) (2 mg/kg), Cisplatin (2 mg/kg), or Cisplatin (2 mg/kg) and Brusatol (2 mg/kg) combined treatment is i.p. injected every other day for a total of five times. Cisplatin or Brusatol (NSC 172924) alone does not inhibit tumor growth significantly, whereas in the combination group, tumor size is significantly reduced.

"14907-98-3" 相關(guān)產(chǎn)品信息
99132-97-5 95258-13-2 95258-12-1 25514-29-8 95258-15-4 95258-14-3 25514-31-2 21499-66-1 505-52-2 2104-19-0 37443-42-8 85064-61-5