148439-49-0
148439-49-0 結(jié)構(gòu)式
基本信息
PRP106-126, HUMAN
KTNMKHMAGAAAAGAVVGGLG
H-KTNMKHMAGAAAAGAWGGLG-OH
H-KTNMKHMAGAAAAGAVVGGLG-OH
106-126-Prion protein (human)
PRION PEPTIDE (106-126), HUMAN
PRION PROTEIN (106-126) (HUMAN)
PRION PROTEIN FRAGMENT 106-126 HUMAN
106-126-Prion protein PrP (synthetic)
物理化學(xué)性質(zhì)
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-P0305 | PRION PROTEIN (106-126) (HUMAN) PrP 106-126 | 148439-49-0 | 1mg | 800元 |
| 2024/11/08 | HY-P0305 | PRION PROTEIN (106-126) (HUMAN) PrP 106-126 | 148439-49-0 | 5mg | 2000元 |
| 2024/11/08 | HY-P0305 | PRION PROTEIN (106-126) (HUMAN) PrP 106-126 | 148439-49-0 | 10mg | 3000元 |
常見(jiàn)問(wèn)題列表
PrP (106-126) (100 μM) induces mTOR phosphorylation over time in N2a cells. PrP (106-126)-treated cells show significantly increased ROS production in comparison with that of PBS-treated control cells. Knockdown of PRAS40 enhances PrP (106-126)-induced apoptosis. PRAS40 alleviates PrP (106-126)-induced neuronal apoptosis via mTOR-AKT activation. PrP (106-126) interacts selectively with porcine brain endothelial cells (PBEC) via their luminal side, and causes cumulative cell death, as shown by lactate dehydrogenase release, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction, Caspase 3 induction and direct cell counting. In addition, PrP (106-126), but not its corresponding scrambled peptide, produces a 50% reduction of the trans-endothelial electrical resistance, while the PBEC maintained confluency.