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147419-93-0

中文名稱(chēng) 人參皂苷RG6
英文名稱(chēng) Ginsenoside Rg6
CAS 147419-93-0
分子式 C42H70O12
分子量 767
MOL 文件 147419-93-0.mol
更新日期 2023/12/12 15:53:35
147419-93-0 結(jié)構(gòu)式 147419-93-0 結(jié)構(gòu)式

基本信息

中文別名
人參皂苷RG6
人參皂甙 RB6
人參皂苷, 來(lái)源于人參
人參皂苷RG6對(duì)照品,
英文別名
Ginsenoside Rg6
Ginsenoside Rg6 USP/EP/BP
Ginsenoside Rg6, 98%, from Panax ginseng C. A. Mey.
daMMar-20(21),24-diene-3β,6α,12β-trihydroxy-6-O-α-L-rhaMnopyranosyl(-1→2)-β-D-glucopyranoside
β-D-Glucopyranoside, (3β,6α,12β)-3,12-dihydroxydammara-20,24-dien-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-
b-D-Glucopyranoside, (3b,6a,12b)-3,12-dihydroxydammara-20,24-dien-6-yl 2-O-(6-deoxy-a-L-mannopyranosyl)-
(3beta,6alpha,12beta)-3,12-Dihydroxydammara-20,24-dien-6-yl 2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside
所屬類(lèi)別
生物化工：植物提取物

物理化學(xué)性質(zhì)

外觀(guān)性狀白色結(jié)晶粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于人參根莖。
沸點(diǎn)850.6±65.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系數(shù)(pKa)12.85±0.70(Predicted)
形態(tài)粉末
顏色White to off-white

應(yīng)用領(lǐng)域

用途1
人參皂苷Rg6是三七中提取的天然化合物，凋亡誘導(dǎo)劑。

常見(jiàn)問(wèn)題列表

生物活性
Ginsenoside Rg6 是從三七中分離得到的成分。在 HepG2 細(xì)胞中 Ginsenoside Rg6 抑制 TNF-α 誘導(dǎo)的 NF-κB 轉(zhuǎn)錄活性， IC50 為 29.34±2.22 μM。Ginsenoside Rg6 還具有細(xì)胞凋亡誘導(dǎo)作用。
靶點(diǎn)

NF-κB

25.12 μM (IC 50 , in SK-Hep1 cell)

NF-κB

29.34 μM (IC 50 , in HepG2 cell)

Apoptosis

體外研究

Ginsenoside Rg6 inhibits TNF-α-induced NF-κB transcriptional activity with an IC 50 of 25.12±1.04 μM in SK-Hep1 cells, consistent with the data from HepG2 cells. Ginsenoside Rg6 exhibits obvious anti-proliferative and apoptosis-inducing effects when it is applied to JK cells in vitro. Ginsenoside Rg6 blocks S arrest in the cell cycle. CCK-8 method shows that after Ginsenoside Rg6 is used, several groups with different concentrations obviously inhibits JK cell proliferation in human lymphocytoma, with evident dose dependency. Based on IC 50 , the median inhibitory concentration of Ginsenoside Rg6 is 83.08 μM.

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