146670-40-8
中文名稱
SR 11237
英文名稱
SR 11237
CAS
146670-40-8
分子式
C24H28O4
分子量
380.48
MOL 文件
146670-40-8.mol
更新日期
2024/10/28 14:51:35
146670-40-8 結(jié)構(gòu)式
基本信息
中文別名
化合物SR11237化合物 T23383
英文別名
BMS649SR 11237
BMS 188649
4-(2-(5,5,8,8-tetraMethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-1,3-dioxolan-2-yl)benzoic acid
4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-benzoicacid
Benzoic acid, 4-[2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1,3-dioxolan-2-yl]-
所屬類別
生物化工：抑制劑常見(jiàn)問(wèn)題列表
生物活性
SR11237 (BMS-649) 是一種視黃醇 X 受體 (RXR) 選擇性激動(dòng)劑，沒(méi)有任何 RAR 活性。SR11237可導(dǎo)致 RXR/RXR 同型二聚體形成并激活含有 RXR 反應(yīng)元件的報(bào)告基因。體外研究
Using nuclear receptor co-transfection assays in COS-1 cells, that SR11237 is effective at transactivating a chloramphenicol acetyltransferase reporter gene through RXRs but not retinoic acid receptors.
體內(nèi)研究
SR11237 (BMS-649) (25 mg/kg; i.p.; daily from post-natal days 5 to 15) causes irregular ossification and premature closure of the growth plate.
| Animal Model: | Sprague-Dawley rats |
| Dosage: | 25 mg/kg |
| Administration: | I.p.; daily from post-natal days 5 to 15 |
| Result: | Caused disturbed ossification and bone morphology in rats, including premature growth plate closure and infiltration of ossified tissue through the central epiphysis. |