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142479-62-7

中文名稱 142479-62-7
英文名稱 DELTA-OPIOID RECEPTOR PEPTIDE TRIFLUOROACETATE SALT
CAS 142479-62-7
分子式 C29H45N5O8
分子量 591.7
MOL 文件 142479-62-7.mol
更新日期 2025/01/07 10:41:59
142479-62-7 結(jié)構(gòu)式 142479-62-7 結(jié)構(gòu)式

基本信息

中文別名
化合物GLUTEN EXORPHIN C
英文別名
H-YPISL-OH
exorphin c
exorphin C trifluoroacetate
EXORPHIN C TRIFLUOROACETATE SALT
TYR-PRO-ILE-SER-LEU TRIFLUOROACETATE SALT
L-Leucine, L-tyrosyl-L-prolyl-L-isoleucyl-L-seryl-
DELTA-OPIOID RECEPTOR PEPTIDE TRIFLUOROACETATE SALT

物理化學(xué)性質(zhì)

沸點(diǎn)969.3±65.0 °C(Predicted)
密度1.264±0.06 g/cm3(Predicted)
儲(chǔ)存條件−20°C
溶解度Soluble in DMSO
酸度系數(shù)(pKa)3.30±0.10(Predicted)
形態(tài)Solid
顏色White to off-white

安全數(shù)據(jù)

WGK Germany3

常見(jiàn)問(wèn)題列表

生物活性
Gluten exorphin C 是一種源自谷朊粉的阿片肽。在 GPI 和 MVD 檢測(cè)中，抑制 μ opioid 和 δ opioid 活性，IC50 值分別為 40 μM 和13.5 μM。
靶點(diǎn)

IC50: 40 μM (μ opioid), 13.5 μM (δ opioid)

體外研究

Gluten exorphin C, a novel opioid peptide, is isolated from the pepsin-trypsin-chymotrypsin digest of wheat gluten. Gluten exorphin C is evaluated its opioid activities by the GPI and MVD assays and its receptor affinities by radioreceptor assays. Its IC 50 s are 40 μM and 13.5 μM in the GPI and the MVD assays, respectively. Gluten exorphin C has a structure quite different from any of the endogenous and exogenous opioid peptides ever reported in that the N terminal Tyr is the only aromatic amino acid. The analogs containing Tyr-Pro-X-Ser-Leu are synthesized to study its structure-activity relationship. Peptides in which X is an aromatic amino acid or an aliphatic hydrophobic amino acid has opioid activity.

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