1420071-30-2
中文名稱
無中文名稱
英文名稱
1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
CAS
1420071-30-2
分子式
C22H12BrN3O4S
分子量
494.32
MOL 文件
1420071-30-2.mol
更新日期
2024/12/15 19:35:18
1420071-30-2 結(jié)構(gòu)式
基本信息
中文別名
BIOYMIFI (~90%)BIOYMIFI(有異構(gòu)體批次)
TRAIL受體DR5小分子激動劑(BIOYMIFI)
英文別名
CS-1259BioyMifi
(DR5 ACTIVATOR)
Bioymifi (~90%)
Bioymifi >=98% (HPLC)
Bioymifi, 1420071-30-2
Bioymifi, DR5 Activator
Bioymifi,DR5 Activator, >95%
(Z)-5-(5-[(3-[4-Bromophenyl]-2-imino-4-oxothiazolidin-5-ylidene)methyl]furan-2-yl)isoindoline-1,3-dione
(E)-5-(5-((3-(4-bromophenyl)-2-imino-4-oxothiazolidin-5-ylidene)methyl)furan-2-yl)isoindoline-1,3-dione
所屬類別
生物化工：激動劑抑制劑物理化學性質(zhì)
密度1.75±0.1 g/cm3(Predicted)
儲存條件2-8°C
溶解度DMSO：可溶，2mg/mL，澄清（加熱）
酸度系數(shù)(pKa)9.62±0.20(Predicted)
形態(tài)粉末
顏色orange to dark orange red
(Z)-5-(5-((3-(4-溴苯基)-2-亞氨基-4-氧代噻唑烷-5-亞基)甲基)呋喃-2-基)異吲哚啉-1,3-二酮價格(試劑級)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-18377 | BIOYMIFI Bioymifi | 1420071-30-2 | 5mg | 720元 |
| 2025/02/08 | HY-18377 | BIOYMIFI Bioymifi | 1420071-30-2 | 10mM * 1mLin DMSO | 792元 |
| 2025/02/08 | HY-18377 | BIOYMIFI Bioymifi | 1420071-30-2 | 10mg | 1200元 |
常見問題列表
生物活性
Bioymifi 是一種有效的 TRAIL 受體 DR5 激活劑，與DR5的胞外結(jié)構(gòu)域 (ECD) 結(jié)合，Kd 為 1.2 μM，Bioymifi 可作為單一的誘導劑誘導 DR5 的聚集，導致細胞凋亡。體外研究
Bioymifi (3-10 μM) induces caspase-8-dependent apoptosis. At a 10-μM concentration, Bioymifi induces processing of caspase-3 into smaller fragments.
Bioymifi induces apoptosis via death receptor DR5. Bioymifi promotes DR5 aggregation and activation. Bioymifi shares the same DR5-dependent extrinsic apoptotic pathway with TRAIL. Binding of bioymifi to DR5 recruits FADD, which in turn engages with the apical caspase-8 to form death-inducing signaling complex (DISC) Bioymifi (3-10 μM) induces caspase-8-dependent apoptosis. At a 10-μM concentration, Bioymifi induces processing of caspase-3 into smaller fragments.