1415246-68-2
中文名稱
MONOMETHYLAURISTATIN F HYDROCHLORIDE
英文名稱
MMAF (Hydrochloride)
CAS
1415246-68-2
分子式
C39H66ClN5O8
分子量
768.423
MOL 文件
1415246-68-2.mol
更新日期
2024/11/15 18:20:33
1415246-68-2 結(jié)構(gòu)式
基本信息
中文別名
細(xì)胞分裂抑制劑(MMAF HYDROCHLORIDE) 英文別名
CS-1270MMAF HCl
MMAF (Hydrochloride)
Monomethylauristatin F Hydrochloride
物理化學(xué)性質(zhì)
儲(chǔ)存條件Store at -20°C,unstable in solution, ready to use.
溶解度DMSO: 27 mg/mL (35.14 mM and warming)
形態(tài)Solid
顏色White to off-white
MONOMETHYLAURISTATIN F HYDROCHLORIDE價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-15579A | MONOMETHYLAURISTATIN F HYDROCHLORIDE MMAF hydrochloride | 1415246-68-2 | 5mg | 400元 |
| 2024/11/08 | HY-15579A | MONOMETHYLAURISTATIN F HYDROCHLORIDE MMAF hydrochloride | 1415246-68-2 | 10mg | 560元 |
| 2024/11/08 | HY-15579A | MONOMETHYLAURISTATIN F HYDROCHLORIDE MMAF hydrochloride | 1415246-68-2 | 50 mg | 1280元 |
常見(jiàn)問(wèn)題列表
生物活性
MMAF (Monomethylauristatin F) hydrochloride 是一種有效的微管蛋白聚合 (tubulin polymerization) 抑制劑，用作抗腫瘤藥物。MMAF hydrochloride 廣泛用作抗體偶聯(lián)藥物 (ADCs) 的細(xì)胞毒性成分，如 Vorsetuzumab mafodotin 和 SGN-CD19A。靶點(diǎn)
|
Auristatin
|
體外研究
MMAF inhibits anaplastic large cell lymphoma Karpas 299, breast carcinoma H3396, renal cell carcinoma 786-O and Caki-1 cells with IC 50 s of 119, 105, 257 and 200 nM in vitro cytotoxicity assay.
體內(nèi)研究
The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF 4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF 4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively.