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1404091-23-1

中文名稱 1404091-23-1
英文名稱 NucPE1
CAS 1404091-23-1
分子式 C29H30BNO5
分子量 483.36
MOL 文件 1404091-23-1.mol
更新日期 2023/03/20 15:41:25
1404091-23-1 結(jié)構(gòu)式 1404091-23-1 結(jié)構(gòu)式

基本信息

中文別名
化合物 T19042
英文別名
NucPE1
NUCPE1?, >98%
Nuclear Peroxy Emerald 1
Nuclear Peroxy Emerald 1, >98%

物理化學(xué)性質(zhì)

沸點643.5±55.0 °C(Predicted)
密度1.26±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)3.40±0.20(Predicted)
形態(tài)Solid
顏色White to off-white
1404091-23-1價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/05HY-1018591404091-23-1
NucPE1
1404091-23-11mg1500元
2025/02/05HY-1018591404091-23-1
NucPE1
1404091-23-15mg4500元
2024/08/19HY-1018591404091-23-1
NucPE1
1404091-23-110mg7500元

常見問題列表

生物活性
NucPE1 (Nuclear Peroxy Emerald 1) 是核定位熒光過氧化氫探針, 其特異性定位于細(xì)胞核,沒有附加的靶向部分。
體外研究

NucPE1 features two major visible region absorptions (λ abs =468 nm, ε=27,300 M -1 cm -1 ; λ abs =490 nm, ε=26,000 M -1 cm -1 ) and a weak emission (λ em =530 nm, Φ=0.117). Reaction of NucPE1 with H 2 O 2 triggers a fluorescence increase upon its conversion to fluorophore NucPE1, which possesses one major absorption band at 505 nm (ε=19,100 M -1 cm -1 ) with enhanced emission (λ em =530 nm, Φ=0.626). NucPE1 selectively accumulates in the nuclei of a variety of mammalian cell lines as well as in whole model organisms like C. clegans , where it can respond to subcellular changes in H 2 O 2 fluxes.

體內(nèi)研究

NucPE1 maintains the ability to selectively target nuclei in vivo . NucPE1 imaging reveals a reduction in nuclear H 2 O 2 levels in worms overexpressing sir-2.1 compared to wildtype congeners, supporting a link between this longevity-promoting sirtuin protein and enhanced regulation of nuclear ROS pools.

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