138794-73-7
中文名稱
138794-73-7
英文名稱
CGP 48664A
CAS
138794-73-7
分子式
C11H15ClN6
分子量
266.73
MOL 文件
138794-73-7.mol
更新日期
2024/12/12 09:51:22
138794-73-7 結(jié)構(gòu)式
基本信息
中文別名
化合物SARDOMOZIDE2-(4-甲脒基-2,3-二氫-1H-茚-1-亞基)肼-1-甲脒基二鹽酸鹽
英文別名
CGP 48664ASardomozide HCl
Sardomozide dihydrochloride
物理化學(xué)性質(zhì)
儲存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度DMSO:25.0(Max Conc. mg/mL);82.46(Max Conc. mM)
形態(tài)A solid
顏色White to off-white
常見問題列表
生物活性
Sardomozide dihydrochloride 是一種 S-腺苷甲硫氨酸脫羧酶 (SAMDC) 抑制劑，其 IC50 值為 5 nM。靶點
IC50: 5 nM (SAMDC)
體外研究
Sardomozide is a S-adenosylmethionine decarboxylase (SAMDC) inhibitor with an IC 50 of 5 nM in cell assay. Following treatment for 48 h with 3 μM Sardomozide, intracellular SAMDC activity is reduced to 10% of control. When the CHO/664 cells are grown in the presence of Sardomozide and during treatment with DENSPM, vacuole formation is not observed, and these cells are growth-inhibited and contain levels of DENSPM similar to the parental CHO cells.