138199-51-6
138199-51-6 結(jié)構(gòu)式
基本信息
LY 285265
Tet-glycine
5-Tetrazolyl-glycine
(tetrazol-5-yl)glycine
(RS)-(TETRAZOL-5-YL)GLYCINE
aMino(2H-tetrazol-5-yl)acetic acid
2H-Tetrazole-5-acetic acid, a-amino-
Amino-(1H-tetrazol-5-yl)-acetic acid
2H-Tetrazole-5-acetic acid, α-amino-
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
EC50: 99 nM (GluN1/GluN2D) and 1.7 μM (GluN1/GluN2A)
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a agonist of N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [
3
H]CGS19755 (IC
50
=98 nM) and [
3
H]glutamate (IC
50
=36 nM) as ligands.
(RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [
3
H]kainate, or [
3
H]glycine (IC
50
s>30 μM).
(RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) induces seizure responses and Fos in the NR1+/+ and NR1-/- mice.
(RS)-(Tetrazol-5-yl)glycine is a highly potent convulsant when given to neonatal rats (ED
50
=0.071 mg/kg; i.p.) .
| Animal Model: | C57BL/6 mice |
| Dosage: | 1.25, 1.5 mg/kg |
| Administration: | IP |
| Result: | Induced seizure responses and Fos. |