1370363-74-8
中文名稱
2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]-
英文名稱
2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]-
CAS
1370363-74-8
分子式
C19H18I2N2O4
分子量
592.17
MOL 文件
1370363-74-8.mol
1370363-74-8 結(jié)構(gòu)式
基本信息
中文別名
化合物CO23化合物 T10855
英文別名
CO23CO23,CO-23
2,4-Imidazolidinedione, 5-[[4-[4-hydroxy-3-(1-methylethyl)phenoxy]-3,5-diiodophenyl]methyl]-
物理化學(xué)性質(zhì)
密度1.878±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
酸度系數(shù)(pKa)8.70±0.10(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
常見問題列表
生物活性
CO23 是一種選擇性的 TRα (甲狀腺激素受體)激動(dòng)劑，用于調(diào)節(jié)生長發(fā)育。CO23 能夠通過血腦屏障轉(zhuǎn)運(yùn)。靶點(diǎn)
TRα
體內(nèi)研究
CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively.
| Animal Model: | Hypothyroid Wistar rats |
| Dosage: | 0.04, 0.8, 2.5, and 5.0 nmol/g |
| Administration: | Ip |
| Result: | Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective. |