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136941-85-0

中文名稱 136941-85-0
英文名稱 PCA 50941
CAS 136941-85-0
分子式 C30H31N3O10S
分子量 625.65
MOL 文件 136941-85-0.mol
136941-85-0 結(jié)構(gòu)式 136941-85-0 結(jié)構(gòu)式

基本信息

中文別名
化合物 T13812
英文別名
PCA 50941
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)ethyl] 5-[(tetrahydro-2H-pyran-2-yl)methyl] ester

物理化學(xué)性質(zhì)

沸點(diǎn)816.6±75.0 °C(Predicted)
密度1.387±0.06 g/cm3(Predicted)
儲存條件-20°C儲存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)2.60±0.70(Predicted)

常見問題列表

生物活性
PCA50941 是 1,4-二氫吡啶衍生物,可用于心血管疾病的研究。
體外研究

PCA50941 (1 μM) shifts the I-V relationship of whole-cell Ca 2+ currents by about 5-10 mV towards more hyperpolarizing potentials. PCA50941 increases further the K(+)-evoked peak to 655 nM. In the presence of 5 mM Ca 2+ , PCA50941 increases the [Ca 2+ ] peaks to 427 nM. PCA50941 potentiates the release of catecholamines from perfused bovine adrenal glands evoked by 30 s pulses of 17.7 mM K + in a manner dependent on the [Ca 2+ ]o.

體內(nèi)研究

PCA50941 (10-120 μM) by intracoronary injection, causes smaller reductions of coronary blood flow (CBF) in goats. PCA50941 (10-300 μM/min) does not modify CBF nor the other hemodynamic variables recorded by i.v. infusions in 4 goats. Intravenous infusion of PCA50941 (100 microg/min) reverses the hemodynamic variables from the shock state to control values within 20 min in 5 of 6 animals.

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