136941-70-3
中文名稱
136941-70-3
英文名稱
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide
CAS
136941-70-3
分子式
C26H24Cl2N2O7S
分子量
579.45
MOL 文件
136941-70-3.mol
136941-70-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10101 英文別名
Calcium channel-modulator-13,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, methyl 3-(3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl ester, S,S-dioxide
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-[3-(1,1-dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl)propyl] 5-methyl ester
物理化學(xué)性質(zhì)
沸點(diǎn)721.2±70.0 °C(Predicted)
密度1.427±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)2.62±0.70(Predicted)
形態(tài)Solid
顏色White to off-white
常見問題列表
生物活性
Calcium channel-modulator-1是鈣離子通道 (calcium channel) 調(diào)節(jié)劑，阻塞主動(dòng)脈收縮的 IC50 值為0.8 μM。靶點(diǎn)
IC50: 0.8 μM (Aortic contraction)
體內(nèi)研究
Oral administration of Calcium channel-modulator-1 (20 mg/kg) causes a 35-37% decrease in systolic blood pressure in spontaneously hypertensive rats. However, iv administration of Calcium channel-modulator-1 to anesthetized spontaneously hypertensive rats causes a decrease in blood pressure which was more pronounced and long-lasting than that of nifedipine.