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135531-86-1

中文名稱 CAMALEXIN
英文名稱 camalexin
CAS 135531-86-1
分子式 C11H8N2S
分子量 200.26
MOL 文件 135531-86-1.mol
更新日期 2024/10/21 09:50:55
135531-86-1 結(jié)構(gòu)式 135531-86-1 結(jié)構(gòu)式

基本信息

中文別名
植保素
35531-86-1
化合物CAMALEXIN
英文別名
camalexin
Camalexine
Camalexin >=98% (HPLC)
3-(Thiazol-2-yl)-1H-indole
1H-Indole, 3-(2-thiazolyl)-
3-(1,3-Thiazol-2-yl)-1H-indole, camalexin

物理化學(xué)性質(zhì)

沸點(diǎn)424.8±47.0 °C(Predicted)
密度1.336±0.06 g/cm3(Predicted)
儲(chǔ)存條件2-8°C
溶解度在DMSO中的溶解度為20mg/mL,澄清
酸度系數(shù)(pKa)15.49±0.30(Predicted)
形態(tài)粉末
顏色白色至淺棕色

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302-H315-H319-H335
危險(xiǎn)品標(biāo)志Xn,Xi
危險(xiǎn)類別碼22-36/37/38
安全說明26-36/37/39-45
WGK Germany3
CAMALEXIN價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/08/19HY-119502CAMALEXIN
Camalexin
135531-86-15mg700元
2024/08/19HY-119502CAMALEXIN
Camalexin
135531-86-110mM * 1mLin DMSO770元
2024/08/19HY-119502CAMALEXIN
Camalexin
135531-86-110mg1150元

常見問題列表

生物活性
Camalexin 是一種植物抗毒素,是從 Camelina sativa 和 Arabidopsis(十字花科植物)中分離出來的,具有抗菌,抗真菌,抗增殖和抗癌活性。Camalexin 可誘導(dǎo)活性氧 (ROS) 的產(chǎn)生。
靶點(diǎn)

Reactive oxygen species (ROS)

體外研究

Camalexin shows antiproliferative activity against a human breast cancer cell line.
For the oomycetes Phytophthora and Pythium Nep1-like proteins (necrosis and ethylene-inducing peptide 1-like proteins) are the initial triggers of Camalexin synthesis and formation of reactive oxygen species (ROS). ROS appear to be of general relevance for Camalexin formation. Chemical induction of ROS, such as by application of acifluorfen, coincided with Camalexin synthesis. In a screen for enhanced susceptibility to Alternaria brassicicola the esa1 mutant is identified, which shows delayed Camalexin induction. Particularly in response to ROS inducing agents reduced Camalexin levels are synthesized. This crucial role for ESA1 is confirmed by the inability of esa1 mutants to synthesize Camalexin in response to Leptosphaeria maculans . An additional mutant that exhibits greatly reduced Camalexin accumulation is ups1 , which is isolated on the basis of diminished expression of a tryptophan biosynthetic enzyme.

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