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1354198-41-6

中文名稱 化合物 T27437
英文名稱 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]-
CAS 1354198-41-6
分子式 C17H12F3N5O3
分子量 391.3
MOL 文件 1354198-41-6.mol
1354198-41-6 結(jié)構(gòu)式 1354198-41-6 結(jié)構(gòu)式

基本信息

中文別名
化合物 T27437
英文別名
GS462808
GS-462808
GS 462808
1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one, 2-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-6-[4-(trifluoromethoxy)phenyl]-

應(yīng)用領(lǐng)域

用途一
GS-462808 is a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine. GS-462808 had lower brain penetration and serendipitously lower activity at the brain isoforms. GS-462808 has an improved CNS window , and improved anti-ischemic potency relative to ranolazine.
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