1351438-26-0
中文名稱
化合物 EST64454 FREE BASE
英文名稱
Ethanone, 1-[4-[2-[[1-(3,4-difluorophenyl)-1H-pyrazol-3-yl]methoxy]ethyl]-1-piperazinyl]-
CAS
1351438-26-0
分子式
C18H22F2N4O2
分子量
364.39
MOL 文件
1351438-26-0.mol
1351438-26-0 結(jié)構(gòu)式
基本信息
中文別名
化合物 EST64454 FREE BASE 英文別名
Ethanone, 1-[4-[2-[[1-(3,4-difluorophenyl)-1H-pyrazol-3-yl]methoxy]ethyl]-1-piperazinyl]-物理化學(xué)性質(zhì)
沸點497.1±45.0 °C(Predicted)
密度1.28±0.1 g/cm3(Predicted)
酸度系數(shù)(pKa)6.33±0.10(Predicted)
應(yīng)用領(lǐng)域
用途一
EST64454 is a σ1 receptor (σ1R) antagonist clinical candidate for the treatment of pain. EST64454 shows an outstanding aqueous solubility, which together with its high permeability in Caco-2 cells will allow its classification as a BCS class I compound. It also shows high metabolic stability.