134578-96-4
134578-96-4 結(jié)構(gòu)式
基本信息
中文別名
化合物 T16395 英文別名
ONO-4057ONO-LB 457
Benzenepropanoic acid, 2-(4-carboxybutoxy)-6-[[(5E)-6-(4-methoxyphenyl)-5-hexen-1-yl]oxy]-
物理化學(xué)性質(zhì)
沸點(diǎn)704.8±60.0 °C(Predicted)
密度1.173±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜
酸度系數(shù)(pKa)4.68±0.10(Predicted)
常見(jiàn)問(wèn)題列表
生物活性
ONO4057 是 Leukotriene B4 受體的拮抗劑，其 IC50 值為 0.7±0.3 μM。靶點(diǎn)
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LTB 4 0.7 μM (IC 50 ) |
體內(nèi)研究
Mean animal survivals of the ONO4057-treated animals significantly prolong to 21.0±4.4 days compare with 12.0±0.6 days in control group. Histological findings from grafts taken on day 7 show that severe focal cellular infiltration is observed in both groups, but the degree of hepatocyte necrosis in ONO4057-treated anmimals is milder than that in control group.