1333207-63-8
1333207-63-8 結(jié)構(gòu)式
基本信息
TRPC6 inhibitor
SAR7334 dihydrochloride
SAR7334 (hydrochloride)
TRCP6 inhibitor(SAR7334)
CPA-1588(dihydrochloride)
TRCP6-IN-1 (hydrochloride)
TRCP 6 INHIBITOR
SAR 7334
SAR-7334
SAR7334 HYDROCHLORIDE
TRCP 6 INHIBITOR
4-{[(1R,2R)-2-[(3R)-3-Aminopiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy}-3-chlorobenzonitrile
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2025/02/08 | HY-15699A | 4-[[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氫-1H-茚-1-基]氧基]-3-氯苯甲腈二鹽酸鹽 SAR7334 hydrochloride | 1333207-63-8 | 1 mg | 760元 |
| 2025/02/08 | HY-15699A | 4-[[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氫-1H-茚-1-基]氧基]-3-氯苯甲腈二鹽酸鹽 SAR7334 hydrochloride | 1333207-63-8 | 5mg | 1900元 |
| 2025/02/08 | HY-15699A | 4-[[(1R,2R)-2-[(3R)-3-氨基-1-哌啶基]-2,3-二氫-1H-茚-1-基]氧基]-3-氯苯甲腈二鹽酸鹽 SAR7334 hydrochloride | 1333207-63-8 | 10mM * 1mLin DMSO | 2090元 |
常見問題列表
IC50: 7.9 nM (TRPC6 currents)
SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca 2+ influx into cells with IC 50 s of 9.5, 282 and 226?nM, whereas TRPC4 and TRPC5-mediated Ca 2+ entry is not affected. SAR7334 (1?μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC 50 of 7.9?nM. SAR7334 (100?nM) substantially reduces TRPC6 currents.
SAR7334 (10?mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).