133162-24-0
中文名稱
Β-AMINOARTEETHER
英文名稱
Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]-
CAS
133162-24-0
分子式
C17H29NO5
分子量
327.42
MOL 文件
133162-24-0.mol
133162-24-0 結(jié)構(gòu)式
基本信息
中文別名
化合物Β-AMINOARTEETHER 英文別名
SM934 free baseβ-Aminoarteether
Ethanamine, 2-[[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy]-
常見問題列表
生物活性
β-Aminoarteether (SM934 free base) 是一種具有口服活性的 Artemisinin 衍生物。β-Aminoarteether 可用于炎癥和自身免疫性疾病的研究，例如狼瘡疾病。體外研究
β-Aminoarteether (SM934;10 μM; 24 hours) treatment directly enhances IL-10 production and suppresses IL-12/23p40 production in primary peritoneal macrophages with IFN-γ stimulation.
In vitro, β-Aminoarteether (SM934) could suppress the Th1 and Th17 polarization, but exerted no influence on Treg differentiation.
體內(nèi)研究
β-Aminoarteether (SM934; 1-10 mg/kg; oral administration; daliy; for 3 months) treatment significantly delays the progression of glomerulonephritis and increases the survival rate of NZB/W F1 mice. β-Aminoarteether treatment promots the IL-10 production of macrophages from NZB/W F1 mice.
| Animal Model: | Female NZB/W F1 mice (Six and half months old) |
| Dosage: | 1 mg/kg, 3 mg/kg, and 10 mg/kg |
| Administration: | Oral administration; daliy; for 3 months |
| Result: | Significantly delayed the progression of glomerulonephritis and increased the survival rate of NZB/W F1 mice. |