131614-02-3
131614-02-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T15188 英文別名
E 6123E ?6123,E?6123
JEQVYSUCZLYBRQ-LBPRGKRZSA-N
4H-Pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 6-(2-chlorophenyl)-9-(cyclopropylcarbonyl)-7,8,9,10-tetrahydro-1,4-diMethyl-, (4S)- (9CI)
常見問(wèn)題列表
生物活性
E-?6123 是一種血小板活化因子 (PAF) 受體拮抗劑。靶點(diǎn)
PAF
體外研究
E-6123 (E6123) partially inhibits the Thapsigargin-induced increase in the levels of interleukin-6 mRNA and interleukin-6 protein. To clarify the role of the concurrently produced cell-associated PAF in the thapsigargin-induced increase in the interleukin-6 mRNA level and interleukin-6 production, the effects of the PAF receptor antagonist E-6123 are examined. E-6123 at 1 and 10 μM partially inhibits the Thapsigargin (46.1 nM)-induced increase in the interleukin-6 mRNA level at 4 h and interleukin-6 production at 8 h.