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131614-02-3

中文名稱 E 6123
英文名稱 E 6123
CAS 131614-02-3
分子式 C23H22ClN5OS
分子量 451.972
MOL 文件 131614-02-3.mol
131614-02-3 結(jié)構(gòu)式 131614-02-3 結(jié)構(gòu)式

基本信息

中文別名
化合物 T15188
英文別名
E 6123
E ?6123,E?6123
JEQVYSUCZLYBRQ-LBPRGKRZSA-N
4H-Pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 6-(2-chlorophenyl)-9-(cyclopropylcarbonyl)-7,8,9,10-tetrahydro-1,4-diMethyl-, (4S)- (9CI)

物理化學(xué)性質(zhì)

儲(chǔ)存條件-20°C儲(chǔ)存
溶解度溶于二甲基亞砜

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
A
危險(xiǎn)性描述N/A
防范說(shuō)明N/A

常見問(wèn)題列表

生物活性
E-?6123 是一種血小板活化因子 (PAF) 受體拮抗劑。
靶點(diǎn)

PAF

體外研究

E-6123 (E6123) partially inhibits the Thapsigargin-induced increase in the levels of interleukin-6 mRNA and interleukin-6 protein. To clarify the role of the concurrently produced cell-associated PAF in the thapsigargin-induced increase in the interleukin-6 mRNA level and interleukin-6 production, the effects of the PAF receptor antagonist E-6123 are examined. E-6123 at 1 and 10 μM partially inhibits the Thapsigargin (46.1 nM)-induced increase in the interleukin-6 mRNA level at 4 h and interleukin-6 production at 8 h.

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