1314958-91-2
中文名稱(chēng)
化合物 T26895
英文名稱(chēng)
BRD 0476
CAS
1314958-91-2
分子式
C35H38N4O8S
分子量
674.76
MOL 文件
1314958-91-2.mol
1314958-91-2 結(jié)構(gòu)式
應(yīng)用領(lǐng)域
用途一
BRD0476, also known as ML187, is a novel suppressor of pancreatic β-cell apoptosis. BRD0476 inhibits interferon-gamma (IFN-γ)-induced Janus kinase 2 (JAK2) and signal transducer and activation of transcription 1 (STAT1) signaling to promote β-cell survival. However, unlike common JAK-STAT pathway inhibitors, BRD0476 inhibits JAK-STAT signaling without suppressing the kinase activity of any JAK. BRD0476 suppresses cytokine-induced β-cell apoptosis.