1314217-69-0
中文名稱(chēng)
AZD8529 mesylate
英文名稱(chēng)
AZD8529 mesylate
CAS
1314217-69-0
更新日期
2023/03/20 15:41:25
分子式
C25H28F3N5O6S
分子量
583.58
MOL 文件
1314217-69-0.mol
1314217-69-0 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO: 41.67 mg/mL (71.40 mM)
形態(tài)Solid
顏色White to off-white
AZD8529 mesylate價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/11/08 | HY-107457A | AZD8529 mesylate AZD-8529 mesylate | 1314217-69-0 | 5mg | 1500元 |
| 2024/11/08 | HY-107457A | AZD8529 mesylate AZD-8529 mesylate | 1314217-69-0 | 10mM * 1mLin DMSO | 1930元 |
| 2024/11/08 | HY-107457A | AZD8529 mesylate AZD-8529 mesylate | 1314217-69-0 | 10mg | 2500元 |
常見(jiàn)問(wèn)題列表
生物活性
AZD-8529 mesylate 是一種有效的，高度選擇性的，可口服的 mGluR2 正向調(diào)節(jié)劑，EC50 值為 285 nM；在 20-25 M 的濃度范圍內(nèi)，對(duì) mGluR1，3，4，5，6，7 和 8 沒(méi)有正向調(diào)節(jié)作用。靶點(diǎn)
|
mGluR2 285 nM (EC 50 ) |
體外研究
AZD-8529 mesylate potentiates the effects of glutamate at mGluR2 with an EC
50
of 195 nM .
AZD-8529 mesylate does not elicit antagonist responses on mGluRs at 25 μM.
體內(nèi)研究
AZD-8529 mesylate (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys.
AZD-8529 mesylate (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats.
| Animal Model: | Sprague-Dawley rats |
| Dosage: | 10 mg/kg, 30 mg/kg |
| Administration: | Intraperitoneal injection; 2 hours before nicotine injections |
| Result: | Decreased the increased extracellular dopamine induced by nicotine (0.4 mg/kg, s.c.) in accumbens shell of freely-moving rats. |