1313730-19-6

基本信息
(S)-2-((S)-2-((2S,3R)-2-氨基-3-羥基丁酰胺基)-3-苯基丙酰胺基)-N-((S)-1-((S)-1-氨基-5-胍基-1-氧代戊-2-基)氨基)-4-甲基-1-氧代戊-2-基)-4-甲基戊酰胺 2,2,2-三氟乙酸鹽
197794-83-5 (Thr1)-TRAP-5 amide
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2025/02/08 | HY-P0226A | 1313730-19-6 TFLLR-NH2(TFA) | 1313730-19-6 | 1mg | 500元 |
2025/02/08 | HY-P0226A | 1313730-19-6 TFLLR-NH2(TFA) | 1313730-19-6 | 5mg | 1500元 |
2025/02/08 | HY-P0226A | TFLLR-NH2(TFA) | 1313730-19-6 | 10 mg | 2500元 |
常見問題列表
EC50: 1.9 μM (PAR1)
PAR1 agonists stimulate concentration-dependent increases in [Ca 2+ ]i and in the proportions of neurones. The maximal increase in [Ca 2+ ]i above basal is detected in response to 10?μm TF-NH2 (peak 196.5±20.4?nM, n=25) when 50–80% of identified neurones responded. SW620 cells cultured in the supernatant of TFLLR-NH2-activated platelets upregulate E-cadherin expression and downregulate the vimentin expression. In the in vitro platelet culture system, a TFLLR-NH2 dose-dependent increase of secreted TGF-β1 is detected in the supernatant.
Injection of TF-NH2 into the rat paw stimulates a marked and sustained oedema. An NK1R antagonist and ablation of sensory nerves with capsaicin inhibit oedema by 44% at 1?h and completely by 5?h. In wild-type but not PAR1 ?/? mice, TF-NH2 stimulates Evans blue extravasation in the bladder, oesophagus, stomach, intestine and pancreas by 2–8 fold. Extravasation in the bladder, oesophagus and stomach is abolished by an NK1R antagonist. TFp-NH2 produces notable contraction at 3-50 μM and relaxation at 0.3-50 μM, in the absence of apamin. The concentration-response curve for TFp-NH2-induced contraction is remarkably shifted left, when the TFp-NH2-induced relaxation is blocked by apamin at 0.1 μM.