1313403-49-4
中文名稱
7-BIA
英文名稱
7-BIA
CAS
1313403-49-4
分子式
C15H18O6
分子量
294.3
MOL 文件
1313403-49-4.mol
更新日期
2023/03/20 15:41:25
1313403-49-4 結(jié)構(gòu)式
物理化學(xué)性質(zhì)
沸點(diǎn)547.9±50.0 °C(Predicted)
密度1.279±0.06 g/cm3(Predicted)
酸度系數(shù)(pKa)11.24±0.20(Predicted)
形態(tài)Solid
顏色Off-white to light yellow
常見問(wèn)題列表
生物活性
7-BIA 是一種受體型蛋白酪氨酸磷酸酶 D (PTPRD) 抑制劑，IC50 值約為 1-3 μM。靶點(diǎn)
IC50: ~1-3 μM (PTPRD), 40 μM (PTPRS)
體外研究
7-BIA (7-butoxy illudalic acid analog) inhibits recombinant human PTPRD and recombinant human PTPRS with IC 50 values of ~1–3 μM and 40 μM, respectively.
體內(nèi)研究
7-BIA (10-20 mg/kg; given i.p.; only once) reduces cocaine self-administration in highly experienced WT mice.
| Animal Model: | WT mice (available cocaine 50 times, 1 mg/kg infusions on FR1 schedule during ≥20 prior sessions) |
| Dosage: | 10 mg/kg, 20 mg/kg |
| Administration: | Given i.p.; only once |
| Result: | Reduced cocaine self-administration in highly experienced WT mice. |