13116-77-3
13116-77-3 結(jié)構(gòu)式
基本信息
中文別名
化合物 T12265 英文別名
NSC-624206N-[3-(4-chlorophenyl)-3,3-disulfanylpropyl]decan-1-aminium chloride
N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride
常見(jiàn)問(wèn)題列表
生物活性
NSC624206 是一種泛素 E1 (UBA1) 抑制劑，其 IC50 值為 ~9 μM。NSC624206 特異性地阻斷泛素-硫代酯的形成，但對(duì)泛素腺化無(wú)影響。靶點(diǎn)
IC50: ~9 μM (ubiquitin E1)
體外研究
NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line.
NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC
50
of 13 μM.
NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells.
Western Blot Analysis
| Cell Line: | Kip16 cells |
| Concentration: | 10 nM-10 μM |
| Incubation Time: | 24 hours |
| Result: | Induced accumulation of p27. |