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131060-14-5

中文名稱(chēng) NB-598
英文名稱(chēng) NB-598
CAS 131060-14-5
分子式 C27H31NOS2
分子量 449.67
MOL 文件 131060-14-5.mol
更新日期 2025/01/15 08:43:23
131060-14-5 結(jié)構(gòu)式 131060-14-5 結(jié)構(gòu)式

基本信息

中文別名
NB598(游離)
英文別名
Benzenemethanamine, 3-([3,3'-bithiophen]-5-ylmethoxy)-N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-ethyl-

物理化學(xué)性質(zhì)

熔點(diǎn)~60 °C
沸點(diǎn)530.7±50.0 °C(Predicted)
密度1.122±0.06 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Sealed in dry,Store in freezer, under -20°C
溶解度DMSO: 14 mg/mL
酸度系數(shù)(pKa)7.04±0.50(Predicted)
形態(tài)solid
顏色white

安全數(shù)據(jù)

安全說(shuō)明22-24/25
WGK Germany3

圖譜信息

NB-598價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/08S0338NB-598
NB 598
131060-14-55mg2275.58元
2024/11/08S0338NB 598131060-14-510mM (1mL in DMSO)2694.51元
2024/11/08S0338NB-598
NB 598
131060-14-525mg7436.15元

常見(jiàn)問(wèn)題列表

生物活性
NB-598 是一種有效的競(jìng)爭(zhēng)性 squalene epoxidase (SE) 的抑制劑。NB-598 可抑制 cholesterol膽固醇 的生物合成。
靶點(diǎn)
TargetValue
squalene epoxidase
()
cholesterol
()
體外研究

NB598 (10 μM) causes a 36±7% reduction in total cholesterol level of MIN6 cells. NB598 causes a significant decrease in cholesterol by 49±2%, 46±7%, and 48±2% from PM, ER, and SG, respectively. NB598 dose-dependently inhibits insulin secretion under both basal (1 mM glucose) and glucose-stimulated (16.7 mM glucose) conditions. NB598 at concentrations up to 10 μM does not affect peak outward KV currents or the voltage dependence of activation but increases current inactivation. NB-598 (10 μM) inhibits the synthesis of sterol and sterol ester from [ 14 C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). In the absence of exogenous liposomal cholesterol, NB-598 reduces ACAT activity by 31%. NB-598 reduces ACAT activity by 22% even in the presence of a 600 PM concentration of liposomal cholesterol. NB-598 suppresses the secretion of cholesterol and triacylglycerol from HepG2 cells into the medium.

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