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129121-73-9

中文名稱 ALA-CYS-ASP-THR-ALA-THR-CYS-VAL-THR-HIS-ARG-LEU-ALA-GLY-LEU-LEU-SER-ARG-SER-GLY-GLY-VAL-VAL-LYS-ASN-ASN-PHE-VAL-PRO-THR-ASN-VAL-GLY-SER-LYS-ALA-PHE-NH2: ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2DISULFIDE BRIDGE CYS2-CYS7
英文名稱 ALPHA-CGRP (8-37) (RAT)
CAS 129121-73-9
分子式 C138H224N42O41
分子量 3127.51
MOL 文件 129121-73-9.mol
更新日期 2024/12/22 20:23:43
129121-73-9 結(jié)構(gòu)式 129121-73-9 結(jié)構(gòu)式

基本信息

中文別名
VF-30-NH2
拮抗劑多肽RAT CGRP-(8-37)
英文別名
CGRP 8-37 (RAT)
Rat CGRP-(8-37)
PubChem ID: 90479762
RAT CGRP-(8-37)?, >98%
ALPHA-CGRP (8-37) (RAT)
a-CGRP (8-37) (Mouse, rat)
α-CGRP (8-37) (mouse, rat)
Alpha-CGRP (8-37) (mouse, rat)
VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2
CALCITONIN GENE RELATED PEPTIDE (8-37) RAT

物理化學性質(zhì)

密度1.47±0.1 g/cm3(Predicted)
儲存條件-20°C, protect from light
溶解度H2O : 50 mg/mL (15.99 mM; Need ultrasonic)
形態(tài)固體
顏色White to off-white
水溶解性Soluble to 1 mg/ml in water
序列H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-OH

常見問題列表

生物活性
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) 是高度選擇的 CGRP receptor 拮抗劑。
靶點

CGRP receptor

體外研究

CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor.

體內(nèi)研究

CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels.

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