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1269190-98-8

英文名稱 Phenol, 2-methoxy-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-phenyl-1H-imidazol-5-yl]-
CAS 1269190-98-8
分子式 C23H27N3O2
分子量 377.48
MOL 文件 1269190-98-8.mol
1269190-98-8 結(jié)構(gòu)式 1269190-98-8 結(jié)構(gòu)式

基本信息

英文別名
yGsy2p-IN-H23
Phenol, 2-methoxy-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-phenyl-1H-imidazol-5-yl]-

物理化學(xué)性質(zhì)

沸點(diǎn)545.8±45.0 °C(Predicted)
密度1.19±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
酸度系數(shù)(pKa)9.72±0.20(Predicted)
形態(tài)Solid
顏色Off-white to brown
YGSY2P-IN-H23價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-131177yGsy2p-IN-H231269190-98-85mg2000元
2024/11/08HY-131177yGsy2p-IN-H231269190-98-810mM * 1mLin DMSO2200元
2024/11/08HY-131177yGsy2p-IN-H231269190-98-810mg3500元

常見(jiàn)問(wèn)題列表

生物活性
yGsy2p-IN-H23 是一種有效的酵母糖原合酶 2 (yGsy2p) 抑制劑,對(duì)人糖原合酶 1 (hGYS1) 的 IC50 為 875 μM。yGsy2p-IN-H23 結(jié)合在 yGsy2p 的尿苷二磷酸葡萄糖結(jié)合口袋內(nèi)。yGsy2p-IN-H23 用于糖原儲(chǔ)存疾病 (GSDs) 的相關(guān)研究。
靶點(diǎn)

IC50: 875 μM (hGYS1)

體外研究

yGsy2p-IN-H23 (compound H23) has IC 50 values against either hGYS1Δ634S8,11N or wild-type hGYS1 were 161 μM and 875 μM, respectively. yGsy2p-IN-H23 exhibits IC 50 values of 280 μM and 263 μM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P.

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