1269190-98-8
英文名稱
Phenol, 2-methoxy-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-phenyl-1H-imidazol-5-yl]-
CAS
1269190-98-8
分子式
C23H27N3O2
分子量
377.48
MOL 文件
1269190-98-8.mol
1269190-98-8 結(jié)構(gòu)式
基本信息
英文別名
yGsy2p-IN-H23Phenol, 2-methoxy-4-[1-[2-(1-methyl-2-pyrrolidinyl)ethyl]-4-phenyl-1H-imidazol-5-yl]-
物理化學(xué)性質(zhì)
沸點(diǎn)545.8±45.0 °C(Predicted)
密度1.19±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
酸度系數(shù)(pKa)9.72±0.20(Predicted)
形態(tài)Solid
顏色Off-white to brown
YGSY2P-IN-H23價(jià)格(試劑級(jí))
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-131177 | yGsy2p-IN-H23 | 1269190-98-8 | 5mg | 2000元 |
2024/11/08 | HY-131177 | yGsy2p-IN-H23 | 1269190-98-8 | 10mM * 1mLin DMSO | 2200元 |
2024/11/08 | HY-131177 | yGsy2p-IN-H23 | 1269190-98-8 | 10mg | 3500元 |
常見(jiàn)問(wèn)題列表
生物活性
yGsy2p-IN-H23 是一種有效的酵母糖原合酶 2 (yGsy2p) 抑制劑,對(duì)人糖原合酶 1 (hGYS1) 的 IC50 為 875 μM。yGsy2p-IN-H23 結(jié)合在 yGsy2p 的尿苷二磷酸葡萄糖結(jié)合口袋內(nèi)。yGsy2p-IN-H23 用于糖原儲(chǔ)存疾病 (GSDs) 的相關(guān)研究。靶點(diǎn)
IC50: 875 μM (hGYS1)
體外研究
yGsy2p-IN-H23 (compound H23) has IC 50 values against either hGYS1Δ634S8,11N or wild-type hGYS1 were 161 μM and 875 μM, respectively. yGsy2p-IN-H23 exhibits IC 50 values of 280 μM and 263 μM in the absence and presence of G6P for yGsy2p against yeast and human glycogen synthase (GS), respectively. yGsy2p-IN-H23 is not in direct competition with G6P.