1200126-26-6
英文名稱
GNE 900
CAS
1200126-26-6
分子式
C23H21N5
分子量
367.45
MOL 文件
1200126-26-6.mol
更新日期
2025/03/26 15:36:25
1200126-26-6 結(jié)構(gòu)式
基本信息
英文別名
GNE 900GNE900
GNE 900
PPYHOOZGDDPLKM-UHFFFAOYSA-N
9H-Pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile, 3-[4-(1-piperidinylmethyl)phenyl]-
應(yīng)用領(lǐng)域
用途一
GNE-900 is an ATP-competitive, selective, and orally bioavailable ChK1 inhibitor. In combination with chemotherapeutic agents, GNE-900 sustains ATR/ATM signaling, enhances DNA damage, and induces apoptotic cell death. GNE-900 has little single-agent activity in the absence of chemotherapy and does not grossly potentiate the cytotoxicity of gemcitabine in normal bone marrow cells. In vivo scheduling studies show that optimal administration of the ChK1 inhibitor requires a defined lag between gemcitabine and GNE-900 administration. (Mol Cancer Ther; 12(10); 1968-80).