1198768-91-0
中文名稱
1198768-91-0
英文名稱
EsoMeprazole (MagnesiuM salt)
CAS
1198768-91-0
分子式
C17H19MgN3O3S
分子量
369.721
MOL 文件
1198768-91-0.mol
1198768-91-0 結(jié)構(gòu)式
常見(jiàn)問(wèn)題列表
生物活性
Esomeprazole magnesium salt ((S)-Omeprazole magnesium salt) 是一種有效的具有口服活性質(zhì)子泵抑制劑，可通過(guò)抑制胃壁細(xì)胞中的 H+, K+-ATPase 來(lái)降低酸分泌，并可用于胃食管反流疾病的研究。靶點(diǎn)
H + , K + -ATPase
體外研究
Esomeprazole (25-100 μM; 20 hours; MDA-MB-468 cells) treatment suppresses growth of triple-negative breast cancer cell in vitro in a dose-dependent manner through increase in their intracellular acidification.
Cell Viability Assay
| Cell Line: | MDA-MB-468 cells |
| Concentration: | 25 μM, 50 μM, 75 μM, 100 μM |
| Incubation Time: | 20 hours |
| Result: | Suppressed growth of triple-negative breast cancer cell in vitro in a dose-dependent manner. |
體內(nèi)研究
Esomeprazole (30-300 mg/kg; oral gavage; daily; for 19 or 11 days; C57BL/6J mice) treatment significantly inhibits the progression of fibrosis throughout the lungs of the animals. Esomeprazole also reduces circulating markers of inflammation and fibrosis.
| Animal Model: | C57BL/6J mice (8-weeks old, 25-30 g) treated with cotton smoke-induced lung injury |
| Dosage: | 30 mg/kg, 300 mg/kg |
| Administration: | Oral gavage; daily; for 19 or 11 days |
| Result: | Significantly inhibited the progression of fibrosis throughout the lungs of the animals. |