1191908-14-1
中文名稱
ADRA1D receptor agonist 1
英文名稱
ADRA1D receptor agonist 1
CAS
1191908-14-1
分子式
C15H14Cl2N4O
分子量
337.2
MOL 文件
1191908-14-1.mol
1191908-14-1 結(jié)構(gòu)式
基本信息
中文別名
化合物 T10250ADRA1D RECEPTOR ANTAGONIST 1 鹽酸鹽
英文別名
ADRA1D receptor agonist 1ADRA1D receptor antagonist 1
ADRA1D receptor antagonist 1 HCl
ADRA-1D receptor antagonist 1,ADRA1D receptor antagonist 1
常見問題列表
生物活性
ADRA1D receptor agonist 1 (compound (R)-9S) 是一個高效、選擇性的，有口服活性的 α1D 腎上腺素受拮抗劑，Ki 值為 1.6 nM。靶點
Ki: 1.6 nM (α 1D adrenoceptor)
體外研究
ADRA1D receptor agonist 1 shows low hERG inhibition.
ADRA1D receptor agonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs .
體內(nèi)研究
ADRA1D receptor agonist 1 (4.4 μg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO.
| Animal Model: | Rat with bladder outlet obstruction (BOO) |
| Dosage: | 4.4 μg/kg |
| Administration: | Intravenous injection |
| Result: | Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO. |