1190308-01-0
中文名稱
索非布韋R-磷酸鹽
英文名稱
PSI-7976
CAS
1190308-01-0
分子式
C22H29FN3O9P
分子量
529.45
MOL 文件
1190308-01-0.mol
更新日期
2025/01/14 09:41:24
1190308-01-0 結(jié)構(gòu)式
基本信息
中文別名
磷異構(gòu)體索氟布韋雜質(zhì)6
索非布韋雜質(zhì)19
索非布韋雜質(zhì)01
索福斯布韋雜質(zhì)A
Y008005-A
索非布韋R-磷酸鹽
PSI-7976/ PSI7977雜質(zhì)A
英文別名
PSI-7976SFB-L-Alaninate-Model
Sofosbuvir (R)-Phosphate
Sofosbuvir phosphate salt
N-[[P(R),2'R]-2'-Deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-methylethyl ester
L-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-methyl-P-phenyl-5'-uridylyl]-, 1-methylethyl ester
isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alanite
isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-Lalaninate
(S)-isopropyl 2-((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphorylamino)propanoate
Sofosbuvir impurity 14/ RP-Isomer of Sofosbuvir/Isopropyl ((R)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
物理化學(xué)性質(zhì)
熔點(diǎn)76-82°C
密度1.41±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C冷凍
溶解度可溶于氯仿（少量）、DMSO（少量）、乙酸乙酯（少量）
酸度系數(shù)(pKa)9.39±0.10(Predicted)
形態(tài)固體
顏色白色至灰白色
